diff --git a/crypto/asn1/asn1_lib.c b/crypto/asn1/asn1_lib.c
index 6399de7c2a..52eb16ba9c 100644
--- a/crypto/asn1/asn1_lib.c
+++ b/crypto/asn1/asn1_lib.c
@@ -383,7 +383,7 @@ const unsigned char *ASN1_STRING_get0_data(const ASN1_STRING *x)
     return x->data;
 }
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 unsigned char *ASN1_STRING_data(ASN1_STRING *x)
 {
     return x->data;
diff --git a/crypto/bio/b_sock.c b/crypto/bio/b_sock.c
index 8e40d8644c..78bcffdb13 100644
--- a/crypto/bio/b_sock.c
+++ b/crypto/bio/b_sock.c
@@ -24,7 +24,7 @@
 static int wsa_init_done = 0;
 # endif
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 int BIO_get_host_ip(const char *str, unsigned char *ip)
 {
     BIO_ADDRINFO *res = NULL;
@@ -103,7 +103,7 @@ int BIO_sock_error(int sock)
         return j;
 }
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 struct hostent *BIO_gethostbyname(const char *name)
 {
     /*
@@ -195,7 +195,7 @@ int BIO_socket_ioctl(int fd, long type, void *arg)
     return i;
 }
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 int BIO_get_accept_socket(char *host, int bind_mode)
 {
     int s = INVALID_SOCKET;
diff --git a/crypto/bn/bn_depr.c b/crypto/bn/bn_depr.c
index 4dbbdc3814..9c1c3d57c8 100644
--- a/crypto/bn/bn_depr.c
+++ b/crypto/bn/bn_depr.c
@@ -13,7 +13,7 @@
  */
 
 #include <openssl/opensslconf.h>
-#if OPENSSL_API_0_9_8
+#ifdef OPENSSL_NO_DEPRECATED_0_9_8
 NON_EMPTY_TRANSLATION_UNIT
 #else
 
diff --git a/crypto/bn/bn_lib.c b/crypto/bn/bn_lib.c
index bdd4caa21d..1e62b96874 100644
--- a/crypto/bn/bn_lib.c
+++ b/crypto/bn/bn_lib.c
@@ -15,7 +15,7 @@
 #include "internal/constant_time.h"
 
 /* This stuff appears to be completely unused, so is deprecated */
-#if !OPENSSL_API_0_9_8
+#ifndef OPENSSL_NO_DEPRECATED_0_9_8
 /*-
  * For a 32 bit machine
  * 2 -   4 ==  128
diff --git a/crypto/conf/conf_sap.c b/crypto/conf/conf_sap.c
index 921ff77085..2c5ee2a131 100644
--- a/crypto/conf/conf_sap.c
+++ b/crypto/conf/conf_sap.c
@@ -27,7 +27,7 @@
 
 static int openssl_configured = 0;
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 void OPENSSL_config(const char *appname)
 {
     OPENSSL_INIT_SETTINGS settings;
diff --git a/crypto/dh/dh_depr.c b/crypto/dh/dh_depr.c
index f0903ca20a..09403f6ad5 100644
--- a/crypto/dh/dh_depr.c
+++ b/crypto/dh/dh_depr.c
@@ -10,7 +10,7 @@
 /* This file contains deprecated functions as wrappers to the new ones */
 
 #include <openssl/opensslconf.h>
-#if OPENSSL_API_0_9_8
+#ifdef OPENSSL_NO_DEPRECATED_0_9_8
 NON_EMPTY_TRANSLATION_UNIT
 #else
 
diff --git a/crypto/dsa/dsa_depr.c b/crypto/dsa/dsa_depr.c
index e97eaf124c..2b363e2642 100644
--- a/crypto/dsa/dsa_depr.c
+++ b/crypto/dsa/dsa_depr.c
@@ -20,7 +20,7 @@
 #define xxxHASH    EVP_sha1()
 
 #include <openssl/opensslconf.h>
-#if OPENSSL_API_0_9_8
+#ifdef OPENSSL_NO_DEPRECATED_0_9_8
 NON_EMPTY_TRANSLATION_UNIT
 #else
 
diff --git a/crypto/engine/eng_all.c b/crypto/engine/eng_all.c
index 0c5e4bdfd5..2f83b2ec18 100644
--- a/crypto/engine/eng_all.c
+++ b/crypto/engine/eng_all.c
@@ -15,9 +15,10 @@ void ENGINE_load_builtin_engines(void)
     OPENSSL_init_crypto(OPENSSL_INIT_ENGINE_ALL_BUILTIN, NULL);
 }
 
-#if (defined(__OpenBSD__) || defined(__FreeBSD__) || defined(__DragonFly__)) \
-    && !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
+# if (defined(__OpenBSD__) || defined(__FreeBSD__) || defined(__DragonFly__))
 void ENGINE_setup_bsd_cryptodev(void)
 {
 }
+# endif
 #endif
diff --git a/crypto/err/err.c b/crypto/err/err.c
index b56eec8414..28a5db8ad4 100644
--- a/crypto/err/err.c
+++ b/crypto/err/err.c
@@ -659,13 +659,13 @@ static void err_delete_thread_state(void *arg)
     ERR_STATE_free(state);
 }
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 void ERR_remove_thread_state(void *dummy)
 {
 }
 #endif
 
-#if !OPENSSL_API_1_0_0
+#ifndef OPENSSL_NO_DEPRECATED_1_0_0
 void ERR_remove_state(unsigned long pid)
 {
 }
diff --git a/crypto/evp/e_old.c b/crypto/evp/e_old.c
index 02b16d0f97..82e0c1282c 100644
--- a/crypto/evp/e_old.c
+++ b/crypto/evp/e_old.c
@@ -8,7 +8,7 @@
  */
 
 #include <openssl/opensslconf.h>
-#if OPENSSL_API_0_9_8
+#ifdef OPENSSL_NO_DEPRECATED_0_9_8
 NON_EMPTY_TRANSLATION_UNIT
 #else
 
diff --git a/crypto/hmac/hmac.c b/crypto/hmac/hmac.c
index 17cc58717b..6d4d24d77b 100644
--- a/crypto/hmac/hmac.c
+++ b/crypto/hmac/hmac.c
@@ -86,7 +86,7 @@ int HMAC_Init_ex(HMAC_CTX *ctx, const void *key, int len,
     return rv;
 }
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 int HMAC_Init(HMAC_CTX *ctx, const void *key, int len, const EVP_MD *md)
 {
     if (key && md)
diff --git a/crypto/pkcs12/p12_sbag.c b/crypto/pkcs12/p12_sbag.c
index 2b4ca65399..ccb9acb17e 100644
--- a/crypto/pkcs12/p12_sbag.c
+++ b/crypto/pkcs12/p12_sbag.c
@@ -12,7 +12,7 @@
 #include <openssl/pkcs12.h>
 #include "p12_local.h"
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 ASN1_TYPE *PKCS12_get_attr(const PKCS12_SAFEBAG *bag, int attr_nid)
 {
     return PKCS12_get_attr_gen(bag->attrib, attr_nid);
diff --git a/crypto/rand/rand_lib.c b/crypto/rand/rand_lib.c
index 3508cfb25c..c6b4ad3ae4 100644
--- a/crypto/rand/rand_lib.c
+++ b/crypto/rand/rand_lib.c
@@ -896,7 +896,7 @@ int RAND_bytes(unsigned char *buf, int num)
     return rand_bytes_ex(NULL, buf, num);
 }
 
-#if !OPENSSL_API_1_1_0 && !defined(FIPS_MODE)
+#if !defined(OPENSSL_NO_DEPRECATED_1_1_0) && !defined(FIPS_MODE)
 int RAND_pseudo_bytes(unsigned char *buf, int num)
 {
     const RAND_METHOD *meth = RAND_get_rand_method();
diff --git a/crypto/rand/rand_win.c b/crypto/rand/rand_win.c
index 5f67c87c3c..40b0de9209 100644
--- a/crypto/rand/rand_win.c
+++ b/crypto/rand/rand_win.c
@@ -163,7 +163,7 @@ int rand_pool_add_additional_data(RAND_POOL *pool)
     return rand_pool_add(pool, (unsigned char *)&data, sizeof(data), 0);
 }
 
-# if !OPENSSL_API_1_1_0 && !defined(FIPS_MODE)
+# if !defined(OPENSSL_NO_DEPRECATED_1_1_0) && !defined(FIPS_MODE)
 int RAND_event(UINT iMsg, WPARAM wParam, LPARAM lParam)
 {
     RAND_poll();
diff --git a/crypto/rsa/rsa_depr.c b/crypto/rsa/rsa_depr.c
index c34c605859..ed63262645 100644
--- a/crypto/rsa/rsa_depr.c
+++ b/crypto/rsa/rsa_depr.c
@@ -13,7 +13,7 @@
  */
 
 #include <openssl/opensslconf.h>
-#if OPENSSL_API_0_9_8
+#ifdef OPENSSL_NO_DEPRECATED_0_9_8
 NON_EMPTY_TRANSLATION_UNIT
 
 #else
diff --git a/crypto/srp/srp_vfy.c b/crypto/srp/srp_vfy.c
index c4dd5153f2..9505d4265e 100644
--- a/crypto/srp/srp_vfy.c
+++ b/crypto/srp/srp_vfy.c
@@ -525,7 +525,7 @@ int SRP_VBASE_add0_user(SRP_VBASE *vb, SRP_user_pwd *user_pwd)
     return 1;
 }
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /*
  * DEPRECATED: use SRP_VBASE_get1_by_user instead.
  * This method ignores the configured seed and fails for an unknown user.
diff --git a/crypto/x509/x509_d2.c b/crypto/x509/x509_d2.c
index 5beb7034a7..cb0f84a7e8 100644
--- a/crypto/x509/x509_d2.c
+++ b/crypto/x509/x509_d2.c
@@ -74,7 +74,7 @@ int X509_STORE_load_store(X509_STORE *ctx, const char *uri)
 }
 
 /* Deprecated */
-#if OPENSSL_API_LEVEL < 3
+#ifndef OPENSSL_NO_DEPRECATED_3_0
 int X509_STORE_load_locations(X509_STORE *ctx, const char *file,
                               const char *path)
 {
diff --git a/crypto/x509/x509cset.c b/crypto/x509/x509cset.c
index f1992ddcf0..2350995239 100644
--- a/crypto/x509/x509cset.c
+++ b/crypto/x509/x509cset.c
@@ -91,7 +91,7 @@ const ASN1_TIME *X509_CRL_get0_nextUpdate(const X509_CRL *crl)
     return crl->crl.nextUpdate;
 }
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 ASN1_TIME *X509_CRL_get_lastUpdate(X509_CRL *crl)
 {
     return crl->crl.lastUpdate;
diff --git a/include/openssl/bio.h b/include/openssl/bio.h
index f374b83324..ed9ecc6cca 100644
--- a/include/openssl/bio.h
+++ b/include/openssl/bio.h
@@ -704,7 +704,7 @@ int BIO_sock_error(int sock);
 int BIO_socket_ioctl(int fd, long type, void *arg);
 int BIO_socket_nbio(int fd, int mode);
 int BIO_sock_init(void);
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define BIO_sock_cleanup() while(0) continue
 # endif
 int BIO_set_tcp_ndelay(int sock, int turn_on);
diff --git a/include/openssl/bn.h b/include/openssl/bn.h
index beeca9e25f..7cfc791eab 100644
--- a/include/openssl/bn.h
+++ b/include/openssl/bn.h
@@ -67,7 +67,7 @@ extern "C" {
 # define BN_FLG_CONSTTIME        0x04
 # define BN_FLG_SECURE           0x08
 
-# if !OPENSSL_API_0_9_8
+# ifndef OPENSSL_NO_DEPRECATED_0_9_8
 /* deprecated name for the flag */
 #  define BN_FLG_EXP_CONSTTIME BN_FLG_CONSTTIME
 #  define BN_FLG_FREE            0x8000 /* used for debugging */
@@ -539,7 +539,7 @@ BIGNUM *BN_get_rfc3526_prime_4096(BIGNUM *bn);
 BIGNUM *BN_get_rfc3526_prime_6144(BIGNUM *bn);
 BIGNUM *BN_get_rfc3526_prime_8192(BIGNUM *bn);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define get_rfc2409_prime_768 BN_get_rfc2409_prime_768
 #  define get_rfc2409_prime_1024 BN_get_rfc2409_prime_1024
 #  define get_rfc3526_prime_1536 BN_get_rfc3526_prime_1536
diff --git a/include/openssl/comp.h b/include/openssl/comp.h
index 4b2085749e..06ff58100f 100644
--- a/include/openssl/comp.h
+++ b/include/openssl/comp.h
@@ -41,8 +41,8 @@ int COMP_expand_block(COMP_CTX *ctx, unsigned char *out, int olen,
 
 COMP_METHOD *COMP_zlib(void);
 
-#if !OPENSSL_API_1_1_0
-#define COMP_zlib_cleanup() while(0) continue
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
+# define COMP_zlib_cleanup() while(0) continue
 #endif
 
 # ifdef OPENSSL_BIO_H
diff --git a/include/openssl/conf.h b/include/openssl/conf.h
index 5e03991a3d..39bfe570c8 100644
--- a/include/openssl/conf.h
+++ b/include/openssl/conf.h
@@ -96,7 +96,7 @@ int CONF_dump_bio(LHASH_OF(CONF_VALUE) *conf, BIO *out);
 
 DEPRECATEDIN_1_1_0(void OPENSSL_config(const char *config_name))
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # define OPENSSL_no_config() \
     OPENSSL_init_crypto(OPENSSL_INIT_NO_LOAD_CONFIG, NULL)
 #endif
@@ -143,7 +143,7 @@ int CONF_modules_load_file(const char *filename, const char *appname,
                            unsigned long flags);
 void CONF_modules_unload(int all);
 void CONF_modules_finish(void);
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # define CONF_modules_free() while(0) continue
 #endif
 int CONF_module_add(const char *name, conf_init_func *ifunc,
diff --git a/include/openssl/crypto.h b/include/openssl/crypto.h
index 956fab5142..a6020fdd4c 100644
--- a/include/openssl/crypto.h
+++ b/include/openssl/crypto.h
@@ -42,7 +42,7 @@
  */
 # include <openssl/symhacks.h>
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/opensslv.h>
 # endif
 
@@ -50,7 +50,7 @@
 extern "C" {
 #endif
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define SSLeay                  OpenSSL_version_num
 #  define SSLeay_version          OpenSSL_version
 #  define SSLEAY_VERSION_NUMBER   OPENSSL_VERSION_NUMBER
@@ -68,7 +68,7 @@ typedef struct {
     int dummy;
 } CRYPTO_dynlock;
 
-# endif /* OPENSSL_API_1_1_0 */
+# endif /* OPENSSL_NO_DEPRECATED_1_1_0 */
 
 typedef void CRYPTO_RWLOCK;
 
@@ -238,7 +238,7 @@ int CRYPTO_alloc_ex_data(int class_index, void *obj, CRYPTO_EX_DATA *ad,
 int CRYPTO_set_ex_data(CRYPTO_EX_DATA *ad, int idx, void *val);
 void *CRYPTO_get_ex_data(const CRYPTO_EX_DATA *ad, int idx);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /*
  * This function cleans up all "ex_data" state. It mustn't be called under
  * potential race-conditions.
@@ -285,11 +285,11 @@ typedef struct crypto_threadid_st {
 #  define CRYPTO_THREADID_cpy(dest, src)
 #  define CRYPTO_THREADID_hash(id)                      (0UL)
 
-#  if !OPENSSL_API_1_0_0
+#  ifndef OPENSSL_NO_DEPRECATED_1_0_0
 #   define CRYPTO_set_id_callback(func)
 #   define CRYPTO_get_id_callback()                     (NULL)
 #   define CRYPTO_thread_id()                           (0UL)
-#  endif /* OPENSSL_API_1_0_0 */
+#  endif /* OPENSSL_NO_DEPRECATED_1_0_0 */
 
 #  define CRYPTO_set_dynlock_create_callback(dyn_create_function)
 #  define CRYPTO_set_dynlock_lock_callback(dyn_lock_function)
@@ -297,7 +297,7 @@ typedef struct crypto_threadid_st {
 #  define CRYPTO_get_dynlock_create_callback()          (NULL)
 #  define CRYPTO_get_dynlock_lock_callback()            (NULL)
 #  define CRYPTO_get_dynlock_destroy_callback()         (NULL)
-# endif /* OPENSSL_API_1_1_0 */
+# endif /* OPENSSL_NO_DEPRECATED_1_1_0 */
 
 int CRYPTO_set_mem_functions(
         void *(*m) (size_t, const char *, int),
@@ -370,7 +370,7 @@ int CRYPTO_mem_leaks(BIO *bio);
 
 /* die if we have to */
 ossl_noreturn void OPENSSL_die(const char *assertion, const char *file, int line);
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define OpenSSLDie(f,l,a) OPENSSL_die((a),(f),(l))
 # endif
 # define OPENSSL_assert(e) \
diff --git a/include/openssl/dh.h b/include/openssl/dh.h
index 0dcb9fc157..1e39e86a33 100644
--- a/include/openssl/dh.h
+++ b/include/openssl/dh.h
@@ -23,7 +23,7 @@
 # include <openssl/bio.h>
 # include <openssl/asn1.h>
 # include <openssl/types.h>
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/bn.h>
 # endif
 # include <openssl/dherr.h>
@@ -40,7 +40,7 @@ extern "C" {
 
 # define DH_FLAG_CACHE_MONT_P     0x01
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /*
  * Does nothing. Previously this switched off constant time behaviour.
  */
diff --git a/include/openssl/dsa.h b/include/openssl/dsa.h
index c8d0c3334a..9697a9cafd 100644
--- a/include/openssl/dsa.h
+++ b/include/openssl/dsa.h
@@ -28,7 +28,7 @@ extern "C" {
 # include <openssl/crypto.h>
 # include <openssl/types.h>
 # include <openssl/bn.h>
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/dh.h>
 # endif
 # include <openssl/dsaerr.h>
@@ -40,7 +40,7 @@ extern "C" {
 # define OPENSSL_DSA_FIPS_MIN_MODULUS_BITS 1024
 
 # define DSA_FLAG_CACHE_MONT_P   0x01
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /*
  * Does nothing. Previously this switched off constant time behaviour.
  */
diff --git a/include/openssl/ec.h b/include/openssl/ec.h
index c4b701a07d..1ffdb56c6f 100644
--- a/include/openssl/ec.h
+++ b/include/openssl/ec.h
@@ -22,7 +22,7 @@
 # ifndef OPENSSL_NO_EC
 # include <openssl/asn1.h>
 # include <openssl/symhacks.h>
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/bn.h>
 # endif
 # include <openssl/ecerr.h>
diff --git a/include/openssl/engine.h b/include/openssl/engine.h
index 816eb4e2e6..3c9648dc02 100644
--- a/include/openssl/engine.h
+++ b/include/openssl/engine.h
@@ -13,14 +13,14 @@
 # pragma once
 
 # include <openssl/macros.h>
-# if !OPENSSL_API_3
+# ifndef OPENSSL_NO_DEPRECATED_3_0
 #  define HEADER_ENGINE_H
 # endif
 
 # include <openssl/opensslconf.h>
 
 # ifndef OPENSSL_NO_ENGINE
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/bn.h>
 #  include <openssl/rsa.h>
 #  include <openssl/dsa.h>
@@ -326,7 +326,7 @@ int ENGINE_remove(ENGINE *e);
 /* Retrieve an engine from the list by its unique "id" value. */
 ENGINE *ENGINE_by_id(const char *id);
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # define ENGINE_load_openssl() \
     OPENSSL_init_crypto(OPENSSL_INIT_ENGINE_OPENSSL, NULL)
 # define ENGINE_load_dynamic() \
@@ -500,7 +500,7 @@ int ENGINE_set_cmd_defns(ENGINE *e, const ENGINE_CMD_DEFN *defns);
 int ENGINE_set_ex_data(ENGINE *e, int idx, void *arg);
 void *ENGINE_get_ex_data(const ENGINE *e, int idx);
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /*
  * This function previously cleaned up anything that needs it. Auto-deinit will
  * now take care of it so it is no longer required to call this function.
diff --git a/include/openssl/err.h b/include/openssl/err.h
index 25ce42c48d..e5766ee241 100644
--- a/include/openssl/err.h
+++ b/include/openssl/err.h
@@ -332,7 +332,7 @@ int ERR_load_strings_const(const ERR_STRING_DATA *str);
 int ERR_unload_strings(int lib, ERR_STRING_DATA *str);
 int ERR_load_ERR_strings(void);
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # define ERR_load_crypto_strings() \
     OPENSSL_init_crypto(OPENSSL_INIT_LOAD_CRYPTO_STRINGS, NULL)
 # define ERR_free_strings() while(0) continue
diff --git a/include/openssl/evp.h b/include/openssl/evp.h
index 87c0169db2..06f8b1f1db 100644
--- a/include/openssl/evp.h
+++ b/include/openssl/evp.h
@@ -526,7 +526,7 @@ void *EVP_CIPHER_CTX_get_cipher_data(const EVP_CIPHER_CTX *ctx);
 void *EVP_CIPHER_CTX_set_cipher_data(EVP_CIPHER_CTX *ctx, void *cipher_data);
 # define EVP_CIPHER_CTX_name(c)         EVP_CIPHER_name(EVP_CIPHER_CTX_cipher(c))
 # define EVP_CIPHER_CTX_type(c)         EVP_CIPHER_type(EVP_CIPHER_CTX_cipher(c))
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define EVP_CIPHER_CTX_flags(c)       EVP_CIPHER_flags(EVP_CIPHER_CTX_cipher(c))
 # endif
 # define EVP_CIPHER_CTX_mode(c)         EVP_CIPHER_mode(EVP_CIPHER_CTX_cipher(c))
@@ -726,7 +726,7 @@ int EVP_DecodeFinal(EVP_ENCODE_CTX *ctx, unsigned
                     char *out, int *outl);
 int EVP_DecodeBlock(unsigned char *t, const unsigned char *f, int n);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define EVP_CIPHER_CTX_init(c)      EVP_CIPHER_CTX_reset(c)
 #  define EVP_CIPHER_CTX_cleanup(c)   EVP_CIPHER_CTX_reset(c)
 # endif
@@ -1005,7 +1005,7 @@ const EVP_CIPHER *EVP_sm4_ofb(void);
 const EVP_CIPHER *EVP_sm4_ctr(void);
 # endif
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define OPENSSL_add_all_algorithms_conf() \
     OPENSSL_init_crypto(OPENSSL_INIT_ADD_ALL_CIPHERS \
                         | OPENSSL_INIT_ADD_ALL_DIGESTS \
diff --git a/include/openssl/idea.h b/include/openssl/idea.h
index 0d208683b3..3e46f2822d 100644
--- a/include/openssl/idea.h
+++ b/include/openssl/idea.h
@@ -51,7 +51,7 @@ void IDEA_ofb64_encrypt(const unsigned char *in, unsigned char *out,
                         int *num);
 void IDEA_encrypt(unsigned long *in, IDEA_KEY_SCHEDULE *ks);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define idea_options          IDEA_options
 #  define idea_ecb_encrypt      IDEA_ecb_encrypt
 #  define idea_set_encrypt_key  IDEA_set_encrypt_key
diff --git a/include/openssl/lhash.h b/include/openssl/lhash.h
index 182104aa51..b1b5aa550a 100644
--- a/include/openssl/lhash.h
+++ b/include/openssl/lhash.h
@@ -98,7 +98,7 @@ void OPENSSL_LH_stats_bio(const OPENSSL_LHASH *lh, BIO *out);
 void OPENSSL_LH_node_stats_bio(const OPENSSL_LHASH *lh, BIO *out);
 void OPENSSL_LH_node_usage_stats_bio(const OPENSSL_LHASH *lh, BIO *out);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define _LHASH OPENSSL_LHASH
 #  define LHASH_NODE OPENSSL_LH_NODE
 #  define lh_error OPENSSL_LH_error
diff --git a/include/openssl/objects.h b/include/openssl/objects.h
index 89aa623d73..9ea91c27c8 100644
--- a/include/openssl/objects.h
+++ b/include/openssl/objects.h
@@ -163,7 +163,7 @@ const void *OBJ_bsearch_ex_(const void *key, const void *base, int num,
 int OBJ_new_nid(int num);
 int OBJ_add_object(const ASN1_OBJECT *obj);
 int OBJ_create(const char *oid, const char *sn, const char *ln);
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # define OBJ_cleanup() while(0) continue
 #endif
 int OBJ_create_objects(BIO *in);
diff --git a/include/openssl/pkcs12.h b/include/openssl/pkcs12.h
index d16cf47750..51d6e8a485 100644
--- a/include/openssl/pkcs12.h
+++ b/include/openssl/pkcs12.h
@@ -61,7 +61,7 @@ typedef struct pkcs12_bag_st PKCS12_BAGS;
 
 /* Compatibility macros */
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 
 # define M_PKCS12_bag_type PKCS12_bag_type
 # define M_PKCS12_cert_bag_type PKCS12_cert_bag_type
diff --git a/include/openssl/rand.h b/include/openssl/rand.h
index ca7eceb37d..1cffab7c54 100644
--- a/include/openssl/rand.h
+++ b/include/openssl/rand.h
@@ -42,7 +42,7 @@ int RAND_set_rand_engine(ENGINE *engine);
 
 RAND_METHOD *RAND_OpenSSL(void);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #   define RAND_cleanup() while(0) continue
 # endif
 int RAND_bytes(unsigned char *buf, int num);
diff --git a/include/openssl/rsa.h b/include/openssl/rsa.h
index b70aef5cb5..eba0604455 100644
--- a/include/openssl/rsa.h
+++ b/include/openssl/rsa.h
@@ -23,7 +23,7 @@
 # include <openssl/bio.h>
 # include <openssl/crypto.h>
 # include <openssl/types.h>
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/bn.h>
 # endif
 # include <openssl/rsaerr.h>
@@ -81,13 +81,13 @@ extern "C" {
  * but other engines might not need it
  */
 # define RSA_FLAG_NO_BLINDING            0x0080
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /*
  * Does nothing. Previously this switched off constant time behaviour.
  */
 #  define RSA_FLAG_NO_CONSTTIME           0x0000
 # endif
-# if !OPENSSL_API_0_9_8
+# ifndef OPENSSL_NO_DEPRECATED_0_9_8
 /* deprecated name for the flag*/
 /*
  * new with 0.9.7h; the built-in RSA
diff --git a/include/openssl/ssl.h b/include/openssl/ssl.h
index 9995b87e65..972e2ef827 100644
--- a/include/openssl/ssl.h
+++ b/include/openssl/ssl.h
@@ -22,7 +22,7 @@
 # include <openssl/opensslconf.h>
 # include <openssl/comp.h>
 # include <openssl/bio.h>
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/x509.h>
 #  include <openssl/crypto.h>
 #  include <openssl/buffer.h>
@@ -1125,7 +1125,7 @@ size_t SSL_get_peer_finished(const SSL *s, void *buf, size_t count);
 # define SSL_VERIFY_CLIENT_ONCE          0x04
 # define SSL_VERIFY_POST_HANDSHAKE       0x08
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define OpenSSL_add_ssl_algorithms()   SSL_library_init()
 #  define SSLeay_add_ssl_algorithms()    SSL_library_init()
 # endif
@@ -1500,7 +1500,7 @@ DECLARE_PEM_rw(SSL_SESSION, SSL_SESSION)
 # define SSL_get_shared_curve          SSL_get_shared_group
 
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /* Provide some compatibility macros for removed functionality. */
 #  define SSL_CTX_need_tmp_RSA(ctx)                0
 #  define SSL_CTX_set_tmp_rsa(ctx,rsa)             1
@@ -1630,7 +1630,7 @@ int SSL_add_dir_cert_subjects_to_stack(STACK_OF(X509_NAME) *stackCAs,
 int SSL_add_store_cert_subjects_to_stack(STACK_OF(X509_NAME) *stackCAs,
                                        const char *uri);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define SSL_load_error_strings() \
     OPENSSL_init_ssl(OPENSSL_INIT_LOAD_SSL_STRINGS \
                      | OPENSSL_INIT_LOAD_CRYPTO_STRINGS, NULL)
@@ -1987,7 +1987,7 @@ void SSL_set_accept_state(SSL *s);
 
 __owur long SSL_get_default_timeout(const SSL *s);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define SSL_library_init() OPENSSL_init_ssl(0, NULL)
 # endif
 
@@ -2121,7 +2121,7 @@ __owur int SSL_COMP_get_id(const SSL_COMP *comp);
 STACK_OF(SSL_COMP) *SSL_COMP_get_compression_methods(void);
 __owur STACK_OF(SSL_COMP) *SSL_COMP_set0_compression_methods(STACK_OF(SSL_COMP)
                                                              *meths);
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define SSL_COMP_free_compression_methods() while(0) continue
 # endif
 __owur int SSL_COMP_add_compression_method(int id, COMP_METHOD *cm);
@@ -2173,7 +2173,7 @@ size_t SSL_get_num_tickets(const SSL *s);
 int SSL_CTX_set_num_tickets(SSL_CTX *ctx, size_t num_tickets);
 size_t SSL_CTX_get_num_tickets(const SSL_CTX *ctx);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define SSL_cache_hit(s) SSL_session_reused(s)
 # endif
 
diff --git a/include/openssl/stack.h b/include/openssl/stack.h
index 895dba0c7c..031b672ed1 100644
--- a/include/openssl/stack.h
+++ b/include/openssl/stack.h
@@ -56,7 +56,7 @@ OPENSSL_STACK *OPENSSL_sk_dup(const OPENSSL_STACK *st);
 void OPENSSL_sk_sort(OPENSSL_STACK *st);
 int OPENSSL_sk_is_sorted(const OPENSSL_STACK *st);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define _STACK OPENSSL_STACK
 #  define sk_num OPENSSL_sk_num
 #  define sk_value OPENSSL_sk_value
diff --git a/include/openssl/ui.h b/include/openssl/ui.h
index 4553716362..56fb6f580f 100644
--- a/include/openssl/ui.h
+++ b/include/openssl/ui.h
@@ -12,13 +12,13 @@
 # pragma once
 
 # include <openssl/macros.h>
-# if !OPENSSL_API_3
+# ifndef OPENSSL_NO_DEPRECATED_3_0
 #  define HEADER_UI_H
 # endif
 
 # include <openssl/opensslconf.h>
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/crypto.h>
 # endif
 # include <openssl/safestack.h>
diff --git a/include/openssl/x509.h b/include/openssl/x509.h
index d828e87d03..116b30205c 100644
--- a/include/openssl/x509.h
+++ b/include/openssl/x509.h
@@ -27,7 +27,7 @@
 # include <openssl/safestack.h>
 # include <openssl/ec.h>
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  include <openssl/rsa.h>
 #  include <openssl/dsa.h>
 #  include <openssl/dh.h>
@@ -658,7 +658,7 @@ int X509_set_pubkey(X509 *x, EVP_PKEY *pkey);
 int X509_up_ref(X509 *x);
 int X509_get_signature_type(const X509 *x);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define X509_get_notBefore X509_getm_notBefore
 #  define X509_get_notAfter X509_getm_notAfter
 #  define X509_set_notBefore X509_set1_notBefore
@@ -724,7 +724,7 @@ int X509_CRL_set1_nextUpdate(X509_CRL *x, const ASN1_TIME *tm);
 int X509_CRL_sort(X509_CRL *crl);
 int X509_CRL_up_ref(X509_CRL *crl);
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define X509_CRL_set_lastUpdate X509_CRL_set1_lastUpdate
 #  define X509_CRL_set_nextUpdate X509_CRL_set1_nextUpdate
 #endif
diff --git a/include/openssl/x509_vfy.h b/include/openssl/x509_vfy.h
index 83186bb1aa..651ffbcbe6 100644
--- a/include/openssl/x509_vfy.h
+++ b/include/openssl/x509_vfy.h
@@ -55,7 +55,7 @@ typedef enum {
     X509_LU_X509, X509_LU_CRL
 } X509_LOOKUP_TYPE;
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #define X509_LU_RETRY   -1
 #define X509_LU_FAIL    0
 #endif
@@ -205,7 +205,7 @@ void X509_STORE_CTX_set_depth(X509_STORE_CTX *ctx, int depth);
 
 /* Certificate verify flags */
 
-# if !OPENSSL_API_1_1_0
+# ifndef OPENSSL_NO_DEPRECATED_1_1_0
 #  define X509_V_FLAG_CB_ISSUER_CHECK             0x0   /* Deprecated */
 # endif
 /* Use check time instead of current time */
@@ -375,7 +375,7 @@ X509_STORE_CTX_lookup_certs_fn X509_STORE_CTX_get_lookup_certs(X509_STORE_CTX *c
 X509_STORE_CTX_lookup_crls_fn X509_STORE_CTX_get_lookup_crls(X509_STORE_CTX *ctx);
 X509_STORE_CTX_cleanup_fn X509_STORE_CTX_get_cleanup(X509_STORE_CTX *ctx);
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # define X509_STORE_CTX_get_chain X509_STORE_CTX_get0_chain
 # define X509_STORE_CTX_set_chain X509_STORE_CTX_set0_untrusted
 # define X509_STORE_CTX_trusted_stack X509_STORE_CTX_set0_trusted_stack
diff --git a/include/openssl/x509v3.h b/include/openssl/x509v3.h
index ae16185497..a4004867fc 100644
--- a/include/openssl/x509v3.h
+++ b/include/openssl/x509v3.h
@@ -635,7 +635,7 @@ X509_EXTENSION *X509V3_EXT_i2d(int ext_nid, int crit, void *ext_struc);
 int X509V3_add1_i2d(STACK_OF(X509_EXTENSION) **x, int nid, void *value,
                     int crit, unsigned long flags);
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 /* The new declarations are in crypto.h, but the old ones were here. */
 # define hex_to_string OPENSSL_buf2hexstr
 # define string_to_hex OPENSSL_hexstr2buf
diff --git a/ssl/methods.c b/ssl/methods.c
index 0b03f80160..6118fdbaae 100644
--- a/ssl/methods.c
+++ b/ssl/methods.c
@@ -172,7 +172,7 @@ IMPLEMENT_dtls1_meth_func(DTLS_ANY_VERSION, 0, 0,
                           DTLS_client_method,
                           ssl_undefined_function,
                           ossl_statem_connect, DTLSv1_2_enc_data)
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 # ifndef OPENSSL_NO_TLS1_2_METHOD
 const SSL_METHOD *TLSv1_2_method(void)
 {
diff --git a/ssl/ssl_lib.c b/ssl/ssl_lib.c
index 2c901ff176..74161b0cb7 100644
--- a/ssl/ssl_lib.c
+++ b/ssl/ssl_lib.c
@@ -4243,7 +4243,7 @@ int SSL_CTX_load_verify_store(SSL_CTX *ctx, const char *CAstore)
     return X509_STORE_load_store(ctx->cert_store, CAstore);
 }
 
-#if OPENSSL_API_LEVEL < 3
+#ifndef OPENSSL_NO_DEPRECATED_3_0
 int SSL_CTX_load_verify_locations(SSL_CTX *ctx, const char *CAfile,
                                   const char *CApath)
 {
@@ -4668,7 +4668,7 @@ int SSL_is_server(const SSL *s)
     return s->server;
 }
 
-#if !OPENSSL_API_1_1_0
+#ifndef OPENSSL_NO_DEPRECATED_1_1_0
 void SSL_set_debug(SSL *s, int debug)
 {
     /* Old function was do-nothing anyway... */