diff --git a/Lib/doctest.py b/Lib/doctest.py
index b2ef2ce6367..dafad505ef0 100644
--- a/Lib/doctest.py
+++ b/Lib/doctest.py
@@ -956,7 +956,8 @@ class DocTestFinder:
             return module is inspect.getmodule(object)
         elif inspect.isfunction(object):
             return module.__dict__ is object.__globals__
-        elif inspect.ismethoddescriptor(object):
+        elif (inspect.ismethoddescriptor(object) or
+              inspect.ismethodwrapper(object)):
             if hasattr(object, '__objclass__'):
                 obj_mod = object.__objclass__.__module__
             elif hasattr(object, '__module__'):
diff --git a/Lib/test/doctest_lineno.py b/Lib/test/doctest_lineno.py
index be198513a15..729a68aceaa 100644
--- a/Lib/test/doctest_lineno.py
+++ b/Lib/test/doctest_lineno.py
@@ -48,3 +48,6 @@ class MethodWrapper:
         >>> MethodWrapper.method_with_doctest.__name__
         'method_with_doctest'
         """
+
+# https://github.com/python/cpython/issues/99433
+str_wrapper = object().__str__
diff --git a/Misc/NEWS.d/next/Library/2022-11-13-15-32-19.gh-issue-99433.Ys6y0A.rst b/Misc/NEWS.d/next/Library/2022-11-13-15-32-19.gh-issue-99433.Ys6y0A.rst
new file mode 100644
index 00000000000..8e13a9a66a7
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-11-13-15-32-19.gh-issue-99433.Ys6y0A.rst
@@ -0,0 +1 @@
+Fix :mod:`doctest` failure on :class:`types.MethodWrapperType` in modules.