diff --git a/Misc/NEWS b/Misc/NEWS
index 98814c371ef..9b41b748dfd 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -88,6 +88,9 @@ Windows
 Build
 -----
 
+- Issue #27453: CPP invocation in configure must use CPPFLAGS. Patch by
+  Chi Hsuan Yen.
+
 - Issue #27490: Do not build pgen when cross-compiling.  Patch by Thomas
   Perl.
 
diff --git a/configure b/configure
index da98f6921f4..9970a0dc0fd 100755
--- a/configure
+++ b/configure
@@ -5370,7 +5370,7 @@ cat >> conftest.c <<EOF
 
 EOF
 
-if $CPP conftest.c >conftest.out 2>/dev/null; then
+if $CPP $CPPFLAGS conftest.c >conftest.out 2>/dev/null; then
   PLATFORM_TRIPLET=`grep -v '^#' conftest.out | grep -v '^ *$' | tr -d ' 	'`
   { $as_echo "$as_me:${as_lineno-$LINENO}: result: $PLATFORM_TRIPLET" >&5
 $as_echo "$PLATFORM_TRIPLET" >&6; }
diff --git a/configure.ac b/configure.ac
index 34ce82c7401..1f3aba0997b 100644
--- a/configure.ac
+++ b/configure.ac
@@ -870,7 +870,7 @@ cat >> conftest.c <<EOF
 
 EOF
 
-if $CPP conftest.c >conftest.out 2>/dev/null; then
+if $CPP $CPPFLAGS conftest.c >conftest.out 2>/dev/null; then
   PLATFORM_TRIPLET=`grep -v '^#' conftest.out | grep -v '^ *$' | tr -d ' 	'`
   AC_MSG_RESULT([$PLATFORM_TRIPLET])
 else