diff --git a/Doc/library/urllib.request.rst b/Doc/library/urllib.request.rst
index 1b05458280d..7e79871bbd6 100644
--- a/Doc/library/urllib.request.rst
+++ b/Doc/library/urllib.request.rst
@@ -26,7 +26,7 @@ authentication, redirections, cookies and more.
 The :mod:`urllib.request` module defines the following functions:
 
 
-.. function:: urlopen(url, data=None[, timeout], *, cafile=None, capath=None, cadefault=False, context=None)
+.. function:: urlopen(url, data=None[, timeout], *, context=None)
 
    Open *url*, which can be either a string containing a valid, properly
    encoded URL, or a :class:`Request` object.
@@ -47,14 +47,6 @@ The :mod:`urllib.request` module defines the following functions:
    describing the various SSL options. See :class:`~http.client.HTTPSConnection`
    for more details.
 
-   The optional *cafile* and *capath* parameters specify a set of trusted
-   CA certificates for HTTPS requests.  *cafile* should point to a single
-   file containing a bundle of CA certificates, whereas *capath* should
-   point to a directory of hashed certificate files.  More information can
-   be found in :meth:`ssl.SSLContext.load_verify_locations`.
-
-   The *cadefault* parameter is ignored.
-
    This function always returns an object which can work as a
    :term:`context manager` and has the properties *url*, *headers*, and *status*.
    See :class:`urllib.response.addinfourl` for more detail on these properties.
@@ -115,12 +107,9 @@ The :mod:`urllib.request` module defines the following functions:
       ``http/1.1`` when no *context* is given. Custom *context* should set
       ALPN protocols with :meth:`~ssl.SSLContext.set_alpn_protocol`.
 
-   .. deprecated:: 3.6
-
-       *cafile*, *capath* and *cadefault* are deprecated in favor of *context*.
-       Please use :meth:`ssl.SSLContext.load_cert_chain` instead, or let
-       :func:`ssl.create_default_context` select the system's trusted CA
-       certificates for you.
+    .. versionchanged:: 3.13
+       Remove *cafile*, *capath* and *cadefault* parameters: use the *context*
+       parameter instead.
 
 
 .. function:: install_opener(opener)
diff --git a/Doc/whatsnew/3.13.rst b/Doc/whatsnew/3.13.rst
index 1eb859f3a5a..502cafdaf5e 100644
--- a/Doc/whatsnew/3.13.rst
+++ b/Doc/whatsnew/3.13.rst
@@ -316,6 +316,14 @@ Removed
   method instead.
   (Contributed by Victor Stinner in :gh:`105376`.)
 
+* Remove *cafile*, *capath* and *cadefault* parameters of the
+  :func:`urllib.request.urlopen` function, deprecated in Python 3.6: use the
+  *context* parameter instead. Please use
+  :meth:`ssl.SSLContext.load_cert_chain` instead, or let
+  :func:`ssl.create_default_context` select the system's trusted CA
+  certificates for you.
+  (Contributed by Victor Stinner in :gh:`105382`.)
+
 
 Porting to Python 3.13
 ======================
diff --git a/Lib/test/test_urllib.py b/Lib/test/test_urllib.py
index 2df74f5e6f9..6bb0fb303fa 100644
--- a/Lib/test/test_urllib.py
+++ b/Lib/test/test_urllib.py
@@ -597,15 +597,6 @@ Connection: close
         with warnings_helper.check_warnings(('',DeprecationWarning)):
             urllib.request.URLopener()
 
-    @unittest.skipUnless(ssl, "ssl module required")
-    def test_cafile_and_context(self):
-        context = ssl.create_default_context()
-        with warnings_helper.check_warnings(('', DeprecationWarning)):
-            with self.assertRaises(ValueError):
-                urllib.request.urlopen(
-                    "https://localhost", cafile="/nonexistent/path", context=context
-                )
-
 
 class urlopen_DataTests(unittest.TestCase):
     """Test urlopen() opening a data URL."""
diff --git a/Lib/test/test_urllib2_localnet.py b/Lib/test/test_urllib2_localnet.py
index f4729358557..1c5b027931c 100644
--- a/Lib/test/test_urllib2_localnet.py
+++ b/Lib/test/test_urllib2_localnet.py
@@ -568,31 +568,6 @@ class TestUrlopen(unittest.TestCase):
         data = self.urlopen("https://localhost:%s/bizarre" % handler.port, context=context)
         self.assertEqual(data, b"we care a bit")
 
-    def test_https_with_cafile(self):
-        handler = self.start_https_server(certfile=CERT_localhost)
-        with warnings_helper.check_warnings(('', DeprecationWarning)):
-            # Good cert
-            data = self.urlopen("https://localhost:%s/bizarre" % handler.port,
-                                cafile=CERT_localhost)
-            self.assertEqual(data, b"we care a bit")
-            # Bad cert
-            with self.assertRaises(urllib.error.URLError) as cm:
-                self.urlopen("https://localhost:%s/bizarre" % handler.port,
-                             cafile=CERT_fakehostname)
-            # Good cert, but mismatching hostname
-            handler = self.start_https_server(certfile=CERT_fakehostname)
-            with self.assertRaises(urllib.error.URLError) as cm:
-                self.urlopen("https://localhost:%s/bizarre" % handler.port,
-                             cafile=CERT_fakehostname)
-
-    def test_https_with_cadefault(self):
-        handler = self.start_https_server(certfile=CERT_localhost)
-        # Self-signed cert should fail verification with system certificate store
-        with warnings_helper.check_warnings(('', DeprecationWarning)):
-            with self.assertRaises(urllib.error.URLError) as cm:
-                self.urlopen("https://localhost:%s/bizarre" % handler.port,
-                             cadefault=True)
-
     def test_https_sni(self):
         if ssl is None:
             self.skipTest("ssl module required")
diff --git a/Lib/urllib/request.py b/Lib/urllib/request.py
index 5314b3f2602..1d03259b918 100644
--- a/Lib/urllib/request.py
+++ b/Lib/urllib/request.py
@@ -136,7 +136,7 @@ __version__ = '%d.%d' % sys.version_info[:2]
 
 _opener = None
 def urlopen(url, data=None, timeout=socket._GLOBAL_DEFAULT_TIMEOUT,
-            *, cafile=None, capath=None, cadefault=False, context=None):
+            *, context=None):
     '''Open the URL url, which can be either a string or a Request object.
 
     *data* must be an object specifying additional data to be sent to
@@ -154,14 +154,6 @@ def urlopen(url, data=None, timeout=socket._GLOBAL_DEFAULT_TIMEOUT,
     If *context* is specified, it must be a ssl.SSLContext instance describing
     the various SSL options. See HTTPSConnection for more details.
 
-    The optional *cafile* and *capath* parameters specify a set of trusted CA
-    certificates for HTTPS requests. cafile should point to a single file
-    containing a bundle of CA certificates, whereas capath should point to a
-    directory of hashed certificate files. More information can be found in
-    ssl.SSLContext.load_verify_locations().
-
-    The *cadefault* parameter is ignored.
-
 
     This function always returns an object which can work as a
     context manager and has the properties url, headers, and status.
@@ -187,25 +179,7 @@ def urlopen(url, data=None, timeout=socket._GLOBAL_DEFAULT_TIMEOUT,
 
     '''
     global _opener
-    if cafile or capath or cadefault:
-        import warnings
-        warnings.warn("cafile, capath and cadefault are deprecated, use a "
-                      "custom context instead.", DeprecationWarning, 2)
-        if context is not None:
-            raise ValueError(
-                "You can't pass both context and any of cafile, capath, and "
-                "cadefault"
-            )
-        if not _have_ssl:
-            raise ValueError('SSL support not available')
-        context = ssl.create_default_context(ssl.Purpose.SERVER_AUTH,
-                                             cafile=cafile,
-                                             capath=capath)
-        # send ALPN extension to indicate HTTP/1.1 protocol
-        context.set_alpn_protocols(['http/1.1'])
-        https_handler = HTTPSHandler(context=context)
-        opener = build_opener(https_handler)
-    elif context:
+    if context:
         https_handler = HTTPSHandler(context=context)
         opener = build_opener(https_handler)
     elif _opener is None:
diff --git a/Misc/NEWS.d/next/Library/2023-06-06-16-00-03.gh-issue-105382.A1LgzA.rst b/Misc/NEWS.d/next/Library/2023-06-06-16-00-03.gh-issue-105382.A1LgzA.rst
new file mode 100644
index 00000000000..4e6d72745ff
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2023-06-06-16-00-03.gh-issue-105382.A1LgzA.rst
@@ -0,0 +1,3 @@
+Remove *cafile*, *capath* and *cadefault* parameters of the
+:func:`urllib.request.urlopen` function, deprecated in Python 3.6. Patch by
+Victor Stinner.