diff --git a/tools/testing/selftests/openat2/openat2_test.c b/tools/testing/selftests/openat2/openat2_test.c
index 1bddbe934204..7fb902099de4 100644
--- a/tools/testing/selftests/openat2/openat2_test.c
+++ b/tools/testing/selftests/openat2/openat2_test.c
@@ -259,6 +259,16 @@ void test_openat2_flags(void)
 		unlink(path);
 
 		fd = sys_openat2(AT_FDCWD, path, &test->how);
+		if (fd < 0 && fd == -EOPNOTSUPP) {
+			/*
+			 * Skip the testcase if it failed because not supported
+			 * by FS. (e.g. a valid O_TMPFILE combination on NFS)
+			 */
+			ksft_test_result_skip("openat2 with %s fails with %d (%s)\n",
+					      test->name, fd, strerror(-fd));
+			goto next;
+		}
+
 		if (test->err >= 0)
 			failed = (fd < 0);
 		else
@@ -303,7 +313,7 @@ skip:
 		else
 			resultfn("openat2 with %s fails with %d (%s)\n",
 				 test->name, test->err, strerror(-test->err));
-
+next:
 		free(fdpath);
 		fflush(stdout);
 	}