diff --git a/drivers/acpi/x86/s2idle.c b/drivers/acpi/x86/s2idle.c
index 816bf2c34b7a..1c507804fb10 100644
--- a/drivers/acpi/x86/s2idle.c
+++ b/drivers/acpi/x86/s2idle.c
@@ -417,11 +417,15 @@ static int lps0_device_attach(struct acpi_device *adev,
 		mem_sleep_current = PM_SUSPEND_TO_IDLE;
 
 	/*
-	 * Some LPS0 systems, like ASUS Zenbook UX430UNR/i7-8550U, require the
-	 * EC GPE to be enabled while suspended for certain wakeup devices to
-	 * work, so mark it as wakeup-capable.
+	 * Some Intel based LPS0 systems, like ASUS Zenbook UX430UNR/i7-8550U don't
+	 * use intel-hid or intel-vbtn but require the EC GPE to be enabled while
+	 * suspended for certain wakeup devices to work, so mark it as wakeup-capable.
+	 *
+	 * Only enable on !AMD as enabling this universally causes problems for a number
+	 * of AMD based systems.
 	 */
-	acpi_ec_mark_gpe_for_wake();
+	if (!acpi_s2idle_vendor_amd())
+		acpi_ec_mark_gpe_for_wake();
 
 	return 0;
 }